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TABLE 1
Cytotoxic Drugs That May Interfere With Cellular Metabolism of the Nursing Infant


Drug Reason for Concern, Reported Sign or Symptom in Infant, or
Effect on Lactation
Reference No.

Cyclophosphamide Possible immune suppression; unknown effect on growth or
association with carcinogenesis; neutropenia
26, 27
Cyclosporine Possible immune suppression; unknown effect on growth or
association with carcinogenesis
28, 29
Doxorubicin* Possible immune suppression; unknown effect on growth or
association with carcinogenesis
30
Methotrexate Possible immune suppression; unknown effect on growth or
association with carcinogenesis; neutropenia
31

* Drug is concentrated in human milk.




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