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TABLE 1 Cytotoxic Drugs That May Interfere With Cellular Metabolism of the Nursing Infant Drug Reason for Concern, Reported Sign or Symptom in Infant, or Effect on Lactation Reference No. Cyclophosphamide Possible immune suppression; unknown effect on growth or association with carcinogenesis; neutropenia 26, 27 Cyclosporine Possible immune suppression; unknown effect on growth or association with carcinogenesis 28, 29 Doxorubicin* Possible immune suppression; unknown effect on growth or association with carcinogenesis 30 Methotrexate Possible immune suppression; unknown effect on growth or association with carcinogenesis; neutropenia 31 * Drug is concentrated in human milk.

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