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Adverse Reactions to Iodide Therapy of Asthma and Other Pulmonary Diseases

Sumner J. Yaffe M.D., C. Warren Bierman M.D., Howard M. Cann M.D., Sanford N. Cohen M.D., John Freeman M.D., Sydney Segal M.D., Lester F. Soyka M.D., Charles F. Weiss M.D., John C. Ballin Ph.D., Allan K. Done M.D., Pierre S. Del Prato Pharm. D., Louis Farchione M.D., Norman Kretchmer M.D., Godfrey Oakley M.D., Steven Sawchuk M.D., C. P. Scott M.D., Artemis P. Simopoulos M.D., and Gregory Chudzik Pharm. D.

Neonatal deaths from tracheal obstruction caused by congenital goiters have been reported from such widely scattered locales as Buffalo, New York, New York City, Philadelphia, Washington, D.C., Seattle, Tokyo, Japan, and Glasgow, Scotland. The mothers of these infants had asthma and were receiving conventional doses of iodides, either as potassium iodide or as mixtures of bronchodilators and iodides. Because of these deaths, the Committee on Drugs of the American Academy of Pediatrics has reviewed the use of iodides in the therapy of asthma and other chronic pulmonary diseases.

Five current textbooks advocate the use of iodides in chronic asthma.1-5 "Iodide compounds have a stimulating effect on bronchial secretions and represent expectorants of major importance in treating asthma and particularly status asthmaticus."2 The AMA Drug Evaluations6 recommends the use of iodides only for short-term medication. Current Pediatric Therapy7 emphasizes careful patient selection because only an occasional patient may benefit.

Dosage recommendations usually are 300 mg of potassium iodide every two hours in adults1 and 60 mg per year of age four times daily in children.4 These dosage recommendations are many times greater than the 65 mg of organic iodine (T4 and T3) which the average human thyroid gland delivers to the circulation per day, or the estimated daily adult iodide requirement of 200 mg of iodide.8 As a matter of fact, these recommended dosages for iodides represent 10 to 30 times the total body content of iodide!

Many preparations–some of which are available on an over-the-counter (nonprescription) basis–contain iodides, including antiasthmatic preparations, expectorants, and preparations whose trade names may not suggest the presence of iodides.




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