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PEDIATRICS Vol. 100 No. 1 July 1997, pp. 143-152

AMERICAN ACADEMY OF PEDIATRICS:
Alternative Routes of Drug AdministrationAdvantages and Disadvantages (Subject Review)

During the past 20 years, advances in drug formulations and innovative routes of administration have been made. Our understanding of drug transport across tissues has increased. These changes have often resulted in improved patient adherence to the therapeutic regimen and pharmacologic response. The administration of drugs by transdermal or transmucosal routes offers the advantage of being relatively painless. Also, the potential for greater flexibility in a variety of clinical situations exists, often precluding the need to establish intravenous access, which is a particular benefit for children.

This statement focuses on the advantages and disadvantages of alternative routes of drug administration. Issues of particular importance in the care of pediatric patients, especially factors that could lead to drug-related toxicity or adverse responses, are emphasized.

Statement of reaffirmation:

AAP Publications Reaffirmed, January 2007
Pediatrics 2007 119: 1031. [Extract] [Full Text] [PDF]

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